German Journal of Pharmaceuticals and Biomaterials https://gjpb.de/index.php/gjpb <p style="text-align: justify;"><strong>German Journal of Pharmaceuticals and Biomaterials (GJPB) [ p-ISSN: 2750-624X | e-ISSN:2750-6258 ] </strong>is an interdisciplinary peer reviewed open access scientific journal, publishes high-quality experimental and theoretical research that contributes significantly on all aspects of pharmaceutical sciences and biomaterials and their related subjects including their applications in human (covering experimental and clinical therapeutics). The mission is to publish scientific work that has followed laborious methodologies and to contribute to progress and development in both pharmaceuticals and biomaterials. <br />Scientific areas within the scope of this journal include but are not limited to pharmaceutics (all aspects of formulations and drug delivery systems, including oral, pulmonary, nasal, parenteral and transdermal delivery) and biopharmaceutics, including pharmaceutical biotechnology products, biochemistry and microbiology, pharmacology and toxicology, applied separation science (covers all areas of analytical/chromatography techniques), natural product drug discovery, medicinal chemistry, and bioactive polymers. This journal is also interested in work that addresses biomaterials but is not limited to covering all aspects of biomaterials with broad range of physical, biological and chemical sciences that support the design of biomaterials and the clinical/scientific disciplines in which they are used.</p> <p style="text-align: justify;"><strong>Country of Publication:</strong> Germany<br /><strong>Frequency:</strong> Quarterly (4 issues/year)</p> en-US Fri, 09 Aug 2024 08:40:39 -0400 OJS 3.3.0.8 http://blogs.law.harvard.edu/tech/rss 60 Editor https://gjpb.de/index.php/gjpb/article/view/160 <p>German Journal of Pharmaceuticals and Biomaterials</p> EDITOR Copyright (c) 2024 EDITOR https://creativecommons.org/licenses/by/4.0 https://gjpb.de/index.php/gjpb/article/view/160 Fri, 09 Aug 2024 00:00:00 -0400 Silver nanoparticles: A review of the production techniques to reduce toxicological risk in ecosystems and in human health https://gjpb.de/index.php/gjpb/article/view/136 <p>Silver nanoparticles (AgNPs) are being proposed as a new pharmaceutical product because of their antimicrobial properties and eco-toxicological profile. AgNPs can be synthesized by physical or chemical methods. However, green synthesis, the so-called biosynthesis in which organic or biological materials are used, is becoming even more popular as it is economically sustainable and non-toxic. The latter plays a significant role in loading important bioactives during the synthesis. This review discusses the state of the art of using AgNPs as antimicrobial agents and their green synthesis and environmental impact. It focuses on works published since 2019 using new molecules, e.g., plant extracts, acids, bacteria and fungi, as innovative pharmaceuticals against antimicrobial resistance. A bibliometric map of works published since 2022 indexed to the Scopus core collection is also discussed, highlighting the main research areas of this innovative topic. Their physicochemical properties strongly influence the use of AgNPs and impact ecosystems and human health. Several approaches are described for their synthesis, highlighting that the toxicological risk can be mitigated by adopting green-based methodologies.</p> Erica T. dos Santos Lima, Victoria L. Santana dos Santos, Camilla A. S. Valença, Sona Jain, Juliana C. Cardoso, Ricardo L. C. de Albuquerque-Júnior, André M. Lopes, Karolline Krambeck, Patricia Severino, Eliana B. Souto Copyright (c) 2024 Erica T. dos Santos Lima, Victoria L. Santana dos Santos, Camilla A. S. Valença, Sona Jain, Juliana C. Cardoso, Ricardo L. C. de Albuquerque-Júnior, André M. Lopes, Karolline Krambeck, Patricia Severino, Eliana B. Souto https://creativecommons.org/licenses/by/4.0 https://gjpb.de/index.php/gjpb/article/view/136 Fri, 09 Aug 2024 00:00:00 -0400 Ophthalmology: Navigating ocular barriers with advanced nanocarriers https://gjpb.de/index.php/gjpb/article/view/150 <p>The unique anatomy and physiology of the eye present significant challenges for effective drug delivery, necessitating innovative approaches to manage ocular diseases. This review examines the intricate structure of the eye and the barriers that impede drug penetration, including the corneal epithelium, conjunctival tissue, and blood-retinal barriers. Traditional ocular administration routestopical, periocular, and intraocular-often face limitations in drug bioavailability and patient compliance. Recent advancements in nanotechnology offer promising solutions to these challenges. Nanocarriers such as nanoparticles, liposomes, nanosuspension, nanoemulsion, micelles, and dendrimers enhance drug delivery by improving bioavailability, controlling release rates, and minimizing systemic side effects. Factors influencing the efficacy of these nanocarriers include their size, surface charge, and hydrophilic-lipophilic balance. This review highlights the potential of these novel drug delivery systems in treating chronic ocular conditions such as glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy. These advanced technologies are poised to significantly enhance the therapeutic management of ocular diseases by overcoming the inherent ocular barriers and optimizing drug delivery.</p> Sanaul Mustafa Copyright (c) 2024 Sanaul Mustafa https://creativecommons.org/licenses/by/4.0 https://gjpb.de/index.php/gjpb/article/view/150 Fri, 09 Aug 2024 00:00:00 -0400 Enhancing paracetamol compressibility using the co-drying technique: Impact on tablet release profile from direct compression https://gjpb.de/index.php/gjpb/article/view/118 <p>Direct compression is the most acceptable and preferred method for manufacturing tablets. However, the poor flow property and lack of the required compressibility of most active ingredients preclude the direct compression technique. Paracetamol is a widely used analgesic drug, usually formulated in compressed tablet dosage forms. It is a poorly compressible drug with a hefty dose, usually 300 to 500 mg. In addition, Paracetamol exhibits poor flowability and shows the tendency to cap on tableting due to its poor plasticity and compatibility. The present research work developed Paracetamol DC (Directly Compressible) by co-processing with a mixture of Potato starch and Silicon Dioxide in various ratios using co-freezing and co-drying techniques. Paracetamol DC was assessed for multiple pre-compression and post-compression tableting parameters. The marked improvement in flow behavior and compressibility of co-processed Paracetamol was observed. Results of studies showed that Paracetamol DC developed with a 10% mixture containing Potato Starch and Silicon Dioxide in a ratio of 7:3 exhibited better disintegration properties and released more than 50% of the drug within 30 min. The study concluded that the technique of coprocessing poorly compressible drugs such as Paracetamol with starch and silicon dioxide using the co-freezing co-drying technique could enhance the compressibility and flowability of active pharmaceutical ingredients.</p> Shreya Sham Naik, Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Clecy Fernandes Copyright (c) 2024 Shreya Sham Naik, Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Clecy Fernandes https://creativecommons.org/licenses/by/4.0 https://gjpb.de/index.php/gjpb/article/view/118 Fri, 09 Aug 2024 00:00:00 -0400 Statistical analysis of the critical quality attributes of 1,2- dihydroxypropane as a pharmaceutical excipient https://gjpb.de/index.php/gjpb/article/view/128 <p>The constituting ingredients, either active or inactive, directly influence the quality and efficacy of the pharmaceutical medicinal product. One of the most common and versatile excipients used in various industries, including pharmaceuticals, is 1,2-propanediol, propylene glycol, or methyl ethyl glycol. The present work aims to trend the quality characteristics of Methyl ethyl glycol using exploratory process-behavior plots, which are graphical tools for monitoring and improving process performance. This study focused on the assay and water content tests of the initial 34 batches of the manufactured 1,2-Propanediol using a standard analysis method according to the British Pharmacopoeia (BP), which specifies this excipient's quality requirements and limits. Exploratory Shewhart charts, the simplest and most widely used control charts, were plotted using Statistical Process Control (SPC) software. The results showed that the data did not follow a normal distribution, and there were several out-of-control signals from both quality aspects, indicating that the process was unstable and unpredictable even if no results exceeded the specifications criteria. The study suggests that the supplier needs to improve the process control and the quality limits of Methylethylene glycol to ensure its consistency and reliability. The application of SPC techniques is essential for the modern, competitive chemical industry, as they help to reduce variability, enhance quality, and optimize resources. Trending charts provide a quantitative estimation of the current situation and the actions needed for the future improvement of the quality control tests. Future research could explore the impact of the quality variation of 1,2-Propanediol on the performance and stability of the final dosage forms, as well as the potential risks and benefits of using alternative excipients with similar properties.</p> Mostafa Essam Ahmed Mostafa Eissa Copyright (c) 2024 Mostafa Essam Ahmed Mostafa Eissa https://creativecommons.org/licenses/by/4.0 https://gjpb.de/index.php/gjpb/article/view/128 Fri, 09 Aug 2024 00:00:00 -0400